This session will discuss the state-of-the-art of currently available wearable computing systems based on Body Sensor Networks (BSNs). It will focus on the main results achieved in the SPINE project, led by Prof. Fortino’s research group, in terms of defined models, methodology, algorithms and real prototypes (e.g. activity/gesture recognition systems, fall detection systems, mobile ECG processing systems, elbow/knee rehabilitation systems, emotion recognition systems, etc.). The session will also enumerate and discuss future research challenges along with possible solutions in such an exciting research domain.